The Role of Membrane-embedded DUOX2 on Ectodomain Shedding via G protein-coupled Receptor Signaling

Protease-activated receptors (PARs) and the neurokinin 1 receptor (NK1R) belong to the G protein-coupled receptor (GPCR) family. In this review, we focus on the regulatory mechanism of ectodomain shedding by ADAM10/17 metalloprotease via GPCR signaling. PAR2 and NK1R induce membrane blebbing, resulting in phosphatidylserine externalization in the cellular membrane, which is required for ADAM10/17 metalloprotease activation.

Still embedded together binding to membranes regulates Bcl-2 protein interactions

Endocytosis and signalling: intertwining molecular networks

The Role of Membrane-embedded DUOX2 on Ectodomain Shedding via G protein-coupled Receptor Signaling

The Role of Membrane-embedded DUOX2 on Ectodomain Shedding via G protein-coupled Receptor Signaling

A GAIN in understanding autoproteolytic G protein‐coupled receptors and polycystic kidney disease proteins

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation

Biology, Free Full-Text

Biology, Free Full-Text

Intercellular signaling by ectodomain shedding at the synapse: Trends in Neurosciences

A toolkit for studying cell surface shedding of diverse transmembrane receptors